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KMID : 0613820020120050505
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Journal of Life Science
2002 Volume.12 No. 5 p.505 ~ p.514
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Evaluation of the anticonvulsant effect of tropinone derivatives
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Kim Ick-Soo
Suh Duk-Joon
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Abstract
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The aim of this study was to evaluate the anticonvulsant activity of four agents derived from tropinone (T-1: 2,4-dipyrrolylmethenylnortropinone, T-2: 2,4-diphenylmethenylnortropinone, T-3: 2,4-difurfurylmethenylnortropinone, T-4: 2,4-dimethoxyphenylmethenylnortropinone) in NIH Swiss mouse. Pentylenetetrazole (PTZ) was injected via intraperitonium in mouse and Maximal Electroshock (MES) stimulation was through both conjunctivas by electrodes. Tropinone derivatives were treated at 15 minutes before PTZ or MES procedure. PTZ of 25 mg/kg induced generalized seizure in mouse, effects of tropinone derivatives on PTZ-induced seizure were monitored. Compared with control group, T-4 decreased seizure grade most effectively. Also T-4 increased onset time of PTZ-induced seizure. This result showed that T-4 is most effective on PTZ-induced seizure. In MES-induced seizure, T-1 decreased seizure grade and recovery time. nNOS expression in hippocampus and cortex were increased in PTZ- and MES-induced seizure animals compared with control. Pretreatment of tropinone derivatives in PTZ-induced seizure did not affected nNOS expression in brain tissues, but T-1 and T-4 decreased nNOS expression in cortex of MES-induced seizure animals. These findings suggest that tropinone derivatives have specific anticonvulsant activities according to PTZ- and MES-induced seizure. 2,4- dimethoxyphenylmethenylnortropinone is most effective in PTZ-induced seizure and 2,4-dimethoxyphenylmethenylnortropinone is most effective in MES-induced seizure.
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KEYWORD
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tropinone derivatives, anticonvulsant, PTZ, MES, nNOS
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